Pub. Date : 2022 Mar
PMID : 35149934
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rapamycin attenuated podocyte apoptosis via upregulation of nestin in Ang II-induced podocyte injury. | Sirolimus | angiotensinogen | Homo sapiens |
| 2 | The purpose of this study was to investigate the effect of rapamycin on podocyte injury induced by Ang II and to clarify the role and mechanism of nestin in the protective effect of rapamycin of podocyte injury. | Sirolimus | angiotensinogen | Homo sapiens |
| 3 | We observed that Ang II induced podocyte injury both in vivo and in vitro, whereas rapamycin treatment relieved Ang II-induced podocyte injury. | Sirolimus | angiotensinogen | Homo sapiens |
| 4 | CONCLUSION: We demonstrated that rapamycin attenuated podocyte apoptosis via upregulation of nestin expression through the mTOR/P70S6K signaling pathway in an Ang II-induced podocyte injury. | Sirolimus | angiotensinogen | Homo sapiens |