Title : Rapamycin attenuated podocyte apoptosis via upregulation of nestin in Ang II-induced podocyte injury.

Pub. Date : 2022 Mar

PMID : 35149934






3 Functional Relationships(s)
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1 Convincing evidence indicates that the mTOR inhibitor rapamycin could play a fundamental role in protection against podocyte injury. Sirolimus mechanistic target of rapamycin kinase Homo sapiens
2 We further found that nestin co-localized with p-mTOR in glomeruli, and the protective effect of rapamycin was reduced by nestin-siRNA in podocytes. Sirolimus mechanistic target of rapamycin kinase Homo sapiens
3 CONCLUSION: We demonstrated that rapamycin attenuated podocyte apoptosis via upregulation of nestin expression through the mTOR/P70S6K signaling pathway in an Ang II-induced podocyte injury. Sirolimus mechanistic target of rapamycin kinase Homo sapiens