Title : Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans.

Pub. Date : 1986 Jan

PMID : 3514344






1 Functional Relationships(s)
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1 Addition of highly purified human Interleukin-1 to the culture medium of isolated rat islets of Langerhans for 6 days led to 88% inhibition of glucose-induced insulin-release, reduction of islet contents of insulin and glucagon to 31% and 8% respectively, and disintegration of the islets. Glucose interleukin 1 alpha Homo sapiens