Title : Inorganic arsenic promotes apoptosis of human immortal keratinocytes through the TGF-β1/ERK signaling pathway.

Pub. Date : 2022 Jun

PMID : 35142421






2 Functional Relationships(s)
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1 Moreover, the results demonstrated that the ERK inhibitor (PD98059) and TGF-beta1 inhibitor (LY364947) could inhibit the activation of the ERK signaling pathway, thereby reducing the mitochondrial membrane potential, the total apoptosis rate, and the expression of pro-apoptosis-related genes in the cells, while the expression of the antiapoptosis gene Bcl-2 was significantly increased (P < .05). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one mitogen-activated protein kinase 1 Homo sapiens
2 Moreover, the results demonstrated that the ERK inhibitor (PD98059) and TGF-beta1 inhibitor (LY364947) could inhibit the activation of the ERK signaling pathway, thereby reducing the mitochondrial membrane potential, the total apoptosis rate, and the expression of pro-apoptosis-related genes in the cells, while the expression of the antiapoptosis gene Bcl-2 was significantly increased (P < .05). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one mitogen-activated protein kinase 1 Homo sapiens