Pub. Date : 2022 Apr
PMID : 35137954
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages. | Fumarates | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Derivatives of the metabolites itaconate and fumarate, dimethyl itaconate (DMI), 4-octyl itaconate (4OI) and dimethyl fumarate (DMF), limit both expression and release of IL-1beta following NLRP3 inflammasome activation. | Fumarates | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | DMI, 4OI, DMF and monomethyl fumarate (MMF), another fumarate derivative, also directly inhibited biochemical markers of NLRP3 activation in LPS-primed macrophages, mixed glia, OHSCs and human macrophages in response to nigericin and imiquimod, including ASC speck formation, caspase-1 activation, gasdermin D cleavage and IL-1beta release. | Fumarates | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | Furthermore, we highlight itaconate and fumarate derivatives as potential therapeutic options in NLRP3- and IL-1alpha-driven diseases, including in the brain. | Fumarates | NLR family pyrin domain containing 3 | Homo sapiens |