Title : TRPV1-Mediated Microglial Autophagy Attenuates Alzheimer's Disease-Associated Pathology and Cognitive Decline.

Pub. Date : 2021

PMID : 35115924






5 Functional Relationships(s)
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1 In this study, pharmacological activation of TRPV1 with the TRPV1 agonist capsaicin induced autophagy in a TRPV1-dependent manner in both primary microglia and BV2 cells. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
2 In this study, pharmacological activation of TRPV1 with the TRPV1 agonist capsaicin induced autophagy in a TRPV1-dependent manner in both primary microglia and BV2 cells. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
3 In this study, pharmacological activation of TRPV1 with the TRPV1 agonist capsaicin induced autophagy in a TRPV1-dependent manner in both primary microglia and BV2 cells. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
4 TRPV1 agonist capsaicin decreased amyloid and phosphorylated tau pathology and reversed memory deficits by promoting microglia activation, metabolism, and autophagy in 3xTg mice. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus
5 These results indicate that TRPV1 was a potential therapeutic target for AD, which suggests that capsaicin should be further assessed as a possible treatment for AD. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Mus musculus