Title : Pyrroline-5-Carboxylate Reductase 1: a novel target for sensitizing multiple myeloma cells to bortezomib by inhibition of PRAS40-mediated protein synthesis.

Pub. Date : 2022 Feb 1

PMID : 35105345






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Pyrroline-5-carboxylate reductase 1 and 2 (PYCR1 and PYCR2) are two mitochondrial enzymes that facilitate the last step in the glutamine-to-proline conversion. Proline pyrroline-5-carboxylate reductase 1 Homo sapiens
2 In line with the strong expression of PYCR1, we performed a tracer study in RPMI-8226 cells, which revealed an increased conversion of 13C-glutamine to proline in hypoxia. Proline pyrroline-5-carboxylate reductase 1 Homo sapiens