Title : Pharmacological targeting of polyamine and hypusine biosynthesis reduces tumour activity of endometrial cancer.

Pub. Date : 2022 Jul

PMID : 35100927






1 Functional Relationships(s)
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1 We show that the eIF5A1 is significantly upregulated in EC cells compared to control cells (p = 0.000038) and that combined pharmacological targeting of ODC and eIF5A hypusination with cytostatic drugs DFMO and N1-guanyl-1,7-diaminoheptane (GC7), respectively, reduces eIF5A1 activation and synergistically induces apoptosis in EC cells. 2-(7-aminoheptyl)guanidine ornithine decarboxylase 1 Homo sapiens