Pub. Date : 2022 Jul
PMID : 35100927
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ODC is a MYC target gene and rate-limiting enzyme of polyamine biosynthesis and the FDA-approved anti-protozoan drug alpha-difluoromethylornithine (DFMO) inhibits ODC activity and induces polyamine depletion that leads to tumor growth arrest. | Eflornithine | ornithine decarboxylase 1 | Homo sapiens |
| 2 | ODC is a MYC target gene and rate-limiting enzyme of polyamine biosynthesis and the FDA-approved anti-protozoan drug alpha-difluoromethylornithine (DFMO) inhibits ODC activity and induces polyamine depletion that leads to tumor growth arrest. | Eflornithine | ornithine decarboxylase 1 | Homo sapiens |
| 3 | ODC is a MYC target gene and rate-limiting enzyme of polyamine biosynthesis and the FDA-approved anti-protozoan drug alpha-difluoromethylornithine (DFMO) inhibits ODC activity and induces polyamine depletion that leads to tumor growth arrest. | Eflornithine | ornithine decarboxylase 1 | Homo sapiens |
| 4 | ODC is a MYC target gene and rate-limiting enzyme of polyamine biosynthesis and the FDA-approved anti-protozoan drug alpha-difluoromethylornithine (DFMO) inhibits ODC activity and induces polyamine depletion that leads to tumor growth arrest. | Eflornithine | ornithine decarboxylase 1 | Homo sapiens |
| 5 | We show that the eIF5A1 is significantly upregulated in EC cells compared to control cells (p = 0.000038) and that combined pharmacological targeting of ODC and eIF5A hypusination with cytostatic drugs DFMO and N1-guanyl-1,7-diaminoheptane (GC7), respectively, reduces eIF5A1 activation and synergistically induces apoptosis in EC cells. | Eflornithine | ornithine decarboxylase 1 | Homo sapiens |