Pub. Date : 2021
PMID : 35095503
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tranexamic Acid (TA) is a clinically used antifibrinolytic agent that acts as a Lys mimetic to block binding of Plasminogen with Plasminogen activators, preventing conversion of Plasminogen to its proteolytically activated form, Plasmin. | Tranexamic Acid | plasminogen | Homo sapiens |
| 2 | Tranexamic Acid (TA) is a clinically used antifibrinolytic agent that acts as a Lys mimetic to block binding of Plasminogen with Plasminogen activators, preventing conversion of Plasminogen to its proteolytically activated form, Plasmin. | Tranexamic Acid | plasminogen | Homo sapiens |
| 3 | Previous studies suggested that TA may exhibit anticancer activity by blockade of extracellular Plasmin formation. | Tranexamic Acid | plasminogen | Homo sapiens |
| 4 | Results presented herein demonstrate that TA blocks Plasmin-mediated excision of the extracellular domain of the oncoprotein CDCP1. | Tranexamic Acid | plasminogen | Homo sapiens |
| 5 | Based on the ability of TA to mimic Lys and Arg, we hypothesized that TA may perturb multiple processes that involve Lys/Arg-rich protein sequences, and that TA may alter intracellular signaling pathways in addition to blocking extracellular Plasmin production. | Tranexamic Acid | plasminogen | Homo sapiens |
| 6 | Based on the ability of TA to mimic Lys and Arg, we hypothesized that TA may perturb multiple processes that involve Lys/Arg-rich protein sequences, and that TA may alter intracellular signaling pathways in addition to blocking extracellular Plasmin production. | Tranexamic Acid | plasminogen | Homo sapiens |
| 7 | Based on the ability of TA to mimic Lys and Arg, we hypothesized that TA may perturb multiple processes that involve Lys/Arg-rich protein sequences, and that TA may alter intracellular signaling pathways in addition to blocking extracellular Plasmin production. | Tranexamic Acid | plasminogen | Homo sapiens |