Pub. Date : 2022 May
PMID : 35092164
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanistically, we revealed that the enhanced autophagic turnover by RAPA inhibited NLRP3 inflammasome activity through NLRP3 degradation. | Sirolimus | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Mechanistically, we revealed that the enhanced autophagic turnover by RAPA inhibited NLRP3 inflammasome activity through NLRP3 degradation. | Sirolimus | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | While blocking the fusion of autophagosomes with lysosomes by bafilomycin A1(BafA1), the reduced NLRP3 inflammasome activity induced by RAPA was significantly restored, with increased protein levels of NLRP3 and cleaved Casp-1(p10), as well as IL-1beta secretion. | Sirolimus | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | While blocking the fusion of autophagosomes with lysosomes by bafilomycin A1(BafA1), the reduced NLRP3 inflammasome activity induced by RAPA was significantly restored, with increased protein levels of NLRP3 and cleaved Casp-1(p10), as well as IL-1beta secretion. | Sirolimus | NLR family pyrin domain containing 3 | Homo sapiens |