Title : Evidence of telomere attrition and a potential role for DNA damage in systemic sclerosis.

Pub. Date : 2022 Jan 27

PMID : 35086525






1 Functional Relationships(s)
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1 Administration of GSE4-nanoparticles attenuated bleomycin-induced skin fibrosis as measured by Masson"s staining of collagen and reduced Acta2 and Ctgf mRNA expression, whereas transduction of dermal fibroblasts with a lentiviral GSE4 expression vector reduced COL1A1, ACTA2 and CTGF gene expression after stimulation with bleomycin or TGF-beta, in parallel to a reduction of the phospho-histone H2A.X marker of DNA damage. Bleomycin actin alpha 2, smooth muscle Homo sapiens