Title : Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo.

Pub. Date : 2022 Mar

PMID : 35085541






1 Functional Relationships(s)
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1 Further results indicated that inhibition of IRE1 suppressed H2O2 induced cell senescence, IL-1beta-induced cellular reactive oxygen species (ROS) level and the activation of NF-kappaB, PI3K/Akt and MAPK signaling pathways. Hydrogen Peroxide AKT serine/threonine kinase 1 Homo sapiens