Title : Salvianolic acid B alleviates diabetic endothelial and mitochondrial dysfunction by down-regulating apoptosis and mitophagy of endothelial cells.

Pub. Date : 2022 Feb

PMID : 35068334






3 Functional Relationships(s)
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1 BCL2-associated X (BAX), B-cell lymphoma-2 (Bcl-2), Beclin1, Parkin and PTEN Induced Kinase 1 (Pink1) expression was detected by Western blot, immunohistochemistry, and immunofluorescence in thoracic aorta, HG- and CCCP-induced HUVECs. Carbonyl Cyanide m-Chlorophenyl Hydrazone PTEN induced kinase 1 Homo sapiens
2 BCL2-associated X (BAX), B-cell lymphoma-2 (Bcl-2), Beclin1, Parkin and PTEN Induced Kinase 1 (Pink1) expression was detected by Western blot, immunohistochemistry, and immunofluorescence in thoracic aorta, HG- and CCCP-induced HUVECs. Carbonyl Cyanide m-Chlorophenyl Hydrazone PTEN induced kinase 1 Homo sapiens
3 In diabetic thoracic aorta, HG- and CCCP-induced HUVECs, Sal B distinctly increased Bcl-2 expression and reduced BAX, Beclin1, Parkin and Pink1 expression, thereby protecting endothelial cells from apoptosis and mitophagy. Carbonyl Cyanide m-Chlorophenyl Hydrazone PTEN induced kinase 1 Homo sapiens