Title : Structural basis of T cell receptor specificity and cross-reactivity of two HLA-DQ2.5-restricted gluten epitopes in celiac disease.

Pub. Date : 2022 Mar

PMID : 35065967






1 Functional Relationships(s)
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1 In contrast, within the TRAV9-2+ TCR-HLA-DQ2.5-glia-omega1 ternary complex, the p7-Gln was situated in an electrostatic pocket formed by the hypervariable CDR3beta loop of the TCR and Arg70beta from HLA-DQ2.5,a polar network which would not be supported by the p7-Leu residue of DQ2.5-glia-alpha1a. Leucine T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens