Title : Enantioselective Synthesis and Pharmacological Evaluation of Aza-CGP37157-Lipoic Acid Hybrids for the Treatment of Alzheimer's Disease.

Pub. Date : 2022 Jan 4

PMID : 35052616






1 Functional Relationships(s)
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1 Hybrids based on an aza-analogue of CGP37157, a mitochondrial Na+/Ca2+ exchanger antagonist, and lipoic acid were obtained in order to combine in a single molecule the antioxidant and NRF2 induction properties of lipoic acid and the neuroprotective activity of CGP37157. Azathioprine NFE2 like bZIP transcription factor 2 Homo sapiens