Pub. Date : 2022 Feb
PMID : 35042627
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The involvement of ERK1/2 and p38 MAPK in the premature senescence of melanocytes induced by H2O2 through a p53-independent p21 pathway. | Hydrogen Peroxide | tumor protein p53 | Homo sapiens |
| 2 | H2O2 treatment tended to induce premature senescence in melanocytes through a p53-independent p21 pathway. | Hydrogen Peroxide | tumor protein p53 | Homo sapiens |
| 3 | CONCLUSION: H2O2 increases ROS levels, which activates the ERK1/2 and p38 MAPK pathways to induce the premature senescence of melanocytes through p21 via a p53-independent pathway and consequently disrupts melanosome transfer. | Hydrogen Peroxide | tumor protein p53 | Homo sapiens |