Title : SERMs (selective estrogen receptor modulator), acting as estrogen receptor β agonists in hepatocellular carcinoma cells, inhibit the transforming growth factor-α-induced migration via specific inhibition of AKT signaling pathway.

Pub. Date : 2022

PMID : 35007301






4 Functional Relationships(s)
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1 Raloxifene and bazedoxifene but not tamoxifen, significantly suppressed the TGF-alpha-induced HuH7 cell migration. Raloxifene Hydrochloride transforming growth factor alpha Homo sapiens
2 Raloxifene and bazedoxifene also inhibited the phosphorylation of AKT by TGF-alpha. Raloxifene Hydrochloride transforming growth factor alpha Homo sapiens
3 Furthermore, PHTPP, an ERbeta antagonist, significantly reversed the suppression by both raloxifene and bazedoxifene of the TGF-alpha-induced cell migration. Raloxifene Hydrochloride transforming growth factor alpha Homo sapiens
4 Taken together, our results strongly indicate that raloxifene and bazedoxifene, SERMs, suppress the TGF-alpha-induced migration of HCC cells through ERbeta-mediated inhibition of the AKT signaling pathway. Raloxifene Hydrochloride transforming growth factor alpha Homo sapiens