Title : Safinamide protects against amyloid β (Aβ)-induced oxidative stress and cellular senescence in M17 neuronal cells.

Pub. Date : 2022 Jan

PMID : 35001806






2 Functional Relationships(s)
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1 Further, we show that safinamide treatment resulted in decreased mRNA and protein expressions of p21 and plasminogen activator inhibitor-1 (PAI-1). safinamide cyclin dependent kinase inhibitor 1A Homo sapiens
2 Moreover, silencing of Sirtuin1 (SIRT1) abolished the effects of safinamide on the mRNA levels of p21 and PAI-1, as well as SA-beta-gal-positive cells in Abeta1-42 oligomers-induced M17 cells. safinamide cyclin dependent kinase inhibitor 1A Homo sapiens