Pub. Date : 2022 Jan
PMID : 35001557
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ATP is an essential autocrine factor for pancreatic beta-cell signaling and insulin secretion. | Adenosine Triphosphate | insulin | Homo sapiens |
| 2 | ATP has been previously identified as an autocrine signaling factor that is co-released with insulin to modulate and propagate beta-cell activity within islets of Langerhans. | Adenosine Triphosphate | insulin | Homo sapiens |
| 3 | Here, we show that beta-cell activity and insulin secretion essentially rely on the presence of extracellular ATP. | Adenosine Triphosphate | insulin | Homo sapiens |
| 4 | Extensive washing of cells or depletion of extracellular ATP levels by recombinant apyrase reduced (Ca2+ )i oscillations and insulin secretion in pancreatic cell lines and primary beta-cells. | Adenosine Triphosphate | insulin | Homo sapiens |
| 5 | Inhibition of endogenous ecto-ATP nucleotidases increased extracellular ATP levels, along with (Ca2+ )i oscillations and insulin secretion, indicating that there is a constant supply of ATP to the extracellular space. | Adenosine Triphosphate | insulin | Homo sapiens |