Pub. Date : 2022 Apr 1
PMID : 34992144
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Small-molecule NSC59984 induces mutant p53 degradation through a ROS-ERK2-MDM2 axis in cancer cells. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 2 | We used a small-molecule NSC59984 to explore elimination of mutant p53 in cancer cells, and identified an inducible ROS-ERK2-MDM2 axis as a vulnerability for induction of mutant p53 degradation in cancer cells. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 3 | We used a small-molecule NSC59984 to explore elimination of mutant p53 in cancer cells, and identified an inducible ROS-ERK2-MDM2 axis as a vulnerability for induction of mutant p53 degradation in cancer cells. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 4 | High cellular ROS increases the efficacy of NSC59984 targeting mutant p53 degradation and anti-tumor effects. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 5 | Our data suggest that mutant p53 stabilization has a vulnerability under high ROS cellular conditions, which can be exploited by compounds to target mutant p53 protein degradation through the activation of a ROS-ERK2-MDM2 axis in cancer cells. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 6 | Our data suggest that mutant p53 stabilization has a vulnerability under high ROS cellular conditions, which can be exploited by compounds to target mutant p53 protein degradation through the activation of a ROS-ERK2-MDM2 axis in cancer cells. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 7 | Our data suggest that mutant p53 stabilization has a vulnerability under high ROS cellular conditions, which can be exploited by compounds to target mutant p53 protein degradation through the activation of a ROS-ERK2-MDM2 axis in cancer cells. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 8 | Our data suggest that mutant p53 stabilization has a vulnerability under high ROS cellular conditions, which can be exploited by compounds to target mutant p53 protein degradation through the activation of a ROS-ERK2-MDM2 axis in cancer cells. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 9 | Implications: An inducible ROS-ERK2-MDM2 axis exposes a vulnerability in mutant p53 stabilization and can be exploited by small molecule compounds to induce mutant p53 degradation for cancer therapy. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 10 | Implications: An inducible ROS-ERK2-MDM2 axis exposes a vulnerability in mutant p53 stabilization and can be exploited by small molecule compounds to induce mutant p53 degradation for cancer therapy. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |