Pub. Date : 2022
PMID : 34986150
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Poly-glutamine-dependent self-association as a potential mechanism for regulation of androgen receptor activity. | polyglutamine | androgen receptor | Homo sapiens |
| 2 | We also show that the AR-NTD can undergo liquid-liquid phase separation in vitro, with longer polyQ sequences phase separating more readily. | polyglutamine | androgen receptor | Homo sapiens |
| 3 | Moreover, longer polyQ sequences hinder nuclear localization in the absence of hormone and increase the propensity for formation of AR-containing puncta in the nucleus of cells treated with dihydrotestosterone. | polyglutamine | androgen receptor | Homo sapiens |
| 4 | These results lead us to hypothesize that polyQ-dependent liquid-liquid phase separation may provide a mechanism to decrease the transcriptional activity of AR, potentially opening new opportunities to design effective therapies against CRPC and muscular atrophy. | polyglutamine | androgen receptor | Homo sapiens |