Title : Lithium intoxication induced pyroptosis via ROS/NF-κB/NLRP3 inflammasome regulatory networks in kidney of mice.

Pub. Date : 2022 Apr

PMID : 34984798






1 Functional Relationships(s)
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1 In the vitro study, ROS as an upstream signal phosphorylated IkappaBalpha and NF-kappaB, up-regulated the NLRP3 inflammasome, increased caspase3, 6, 7, and 9 to exaggerate inflammation response, finally inducing pyroptosis in renal cells. Reactive Oxygen Species caspase 3 Mus musculus