Pub. Date : 2022 Feb
PMID : 34973531
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ethyl pyruvate attenuates isoproterenol-induced myocardial infarction in rats: Insight to TNF-alpha-mediated apoptotic and necroptotic signaling interplay. | ethyl pyruvate | tumor necrosis factor | Rattus norvegicus |
| 2 | Moreover, EP remarkably attenuated ISO-induced elevation in Tumor Necrosis Factor Alpha (TNF-alpha) and Nuclear factor kappa-B p65 (NF-kappaB) expression, along with Interleukin-6 (IL-6), Monocyte chemoattractant protein 1 (MCP-1) and Inducible nitric oxide synthase (i-NOS) levels. | ethyl pyruvate | tumor necrosis factor | Rattus norvegicus |
| 3 | Moreover, EP remarkably attenuated ISO-induced elevation in Tumor Necrosis Factor Alpha (TNF-alpha) and Nuclear factor kappa-B p65 (NF-kappaB) expression, along with Interleukin-6 (IL-6), Monocyte chemoattractant protein 1 (MCP-1) and Inducible nitric oxide synthase (i-NOS) levels. | ethyl pyruvate | tumor necrosis factor | Rattus norvegicus |
| 4 | Taken together, EP conferred its cardioprotective effect against ISO-induced MI partially through mitigation of TNF-alpha and its downstream inflammatory, apoptotic and necroptotic signaling pathways. | ethyl pyruvate | tumor necrosis factor | Rattus norvegicus |