Title : Tribbles 2 pseudokinase confers enzalutamide resistance in prostate cancer by promoting lineage plasticity.

Pub. Date : 2022 Feb

PMID : 34973338






2 Functional Relationships(s)
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1 Interestingly, we found that TRIB2 downregulates the luminal markers AR (androgen receptor) and CK8 (cytokeratin 8) in prostate cancer cells but upregulates the neuronal transcription factor BRN2 (Brain-2) and the stemness factor SOX2 (SRY-box 2) to induce neuroendocrine characteristics. Phenobarbital androgen receptor Homo sapiens
2 Interestingly, we found that TRIB2 downregulates the luminal markers AR (androgen receptor) and CK8 (cytokeratin 8) in prostate cancer cells but upregulates the neuronal transcription factor BRN2 (Brain-2) and the stemness factor SOX2 (SRY-box 2) to induce neuroendocrine characteristics. Phenobarbital androgen receptor Homo sapiens