Pub. Date : 2021 Dec 29
PMID : 34971698
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glyoxal induces senescence in human keratinocytes through oxidative stress and activation of the AKT/FOXO3a/p27KIP1 pathway. | Glyoxal | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Furthermore, glyoxal-induced senescence bears a unique molecular progression profile: an "early-stage" when AKT-FOXO3a-p27KIP1 pathway mediates cell-cycle arrest, and a "late-stage" senescence maintained by the p16INK4/pRb pathway. | Glyoxal | AKT serine/threonine kinase 1 | Homo sapiens |