Title : Glyoxal Induces Senescence in Human Keratinocytes through Oxidative Stress and Activation of the Protein Kinase B/FOXO3a/p27KIP1 Pathway.

Pub. Date : 2021 Dec 29

PMID : 34971698






1 Functional Relationships(s)
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1 Furthermore, glyoxal-induced senescence bears a unique molecular progression profile: an "early-stage" when AKT-FOXO3a-p27KIP1 pathway mediates cell-cycle arrest, and a "late-stage" senescence maintained by the p16INK4/pRb pathway. Glyoxal RB transcriptional corepressor 1 Homo sapiens