Title : Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-1B agonist.

Pub. Date : 1987 Apr 7

PMID : 3496228






2 Functional Relationships(s)
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1 At the 5HT1A receptor the compound had an IC50 value of 876 nM, providing a 5HT1A/5HT1B ratio of 17 in contrast to the putative 5HT1B selective agent trifluoromethylphenylpiperazine (TFMPP) which had a corresponding ratio of 3.6. 1-(3-trifluoromethylphenyl)piperazine 5-hydroxytryptamine receptor 1B Homo sapiens
2 At the 5HT1A receptor the compound had an IC50 value of 876 nM, providing a 5HT1A/5HT1B ratio of 17 in contrast to the putative 5HT1B selective agent trifluoromethylphenylpiperazine (TFMPP) which had a corresponding ratio of 3.6. 1-(3-trifluoromethylphenyl)piperazine 5-hydroxytryptamine receptor 1B Homo sapiens