Title : Synergistic Interferon-Alpha-Based Combinations for Treatment of SARS-CoV-2 and Other Viral Infections.

Pub. Date : 2021 Dec 11

PMID : 34960758






2 Functional Relationships(s)
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1 RESULTS: While IFNs alone were insufficient to completely abolish replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), IFNalpha, in combination with remdesivir, EIDD-2801, camostat, cycloheximide, or convalescent serum, proved to be more effective. remdesivir interferon alpha 1 Homo sapiens
2 Transcriptome and metabolomic analyses revealed that the IFNalpha-remdesivir combination suppressed SARS-CoV-2-mediated changes in Calu-3 cells and lung organoids, although it altered the homeostasis of uninfected cells and organoids. remdesivir interferon alpha 1 Homo sapiens