Pub. Date : 1987 Jun 5
PMID : 3495533
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PMA, carbachol, and EGF all stimulated rapid accumulation of mRNA for the proto-oncogenes c-fos and c-myc in the normal cells; in the protein kinase C-deficient cells, carbachol and EGF, but not PMA, retained this effect, which was not mimicked by the calcium ionophore A23187. | Carbachol | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | We conclude that, in 1321-N1 cells, induction of c-fos and c-myc mRNA can occur through a protein kinase C-dependent pathway and one or more independent pathways, exemplified by the responses to carbachol and EGF in the protein kinase C-deficient cells. | Carbachol | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |