Pub. Date : 2022 Mar 1
PMID : 34954416
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This indicates this strategy could block the systemic cleavage of Dox-PSA without reducing its efficacy in vivo, which could represent a safer option to treat patients with locally advanced PC. | Doxorubicin | kallikrein related peptidase 3 | Homo sapiens |
| 2 | STATEMENT OF SIGNIFICANCE: This study investigates a new tactic to tackle non-specific cleavage of doxorubicin PSA-activatable prodrug (L-377,202) to treat advanced prostate cancer. | Doxorubicin | kallikrein related peptidase 3 | Homo sapiens |
| 3 | This includes encapsulating Dox-PSA in low temperature-sensitive liposomes to prevent its premature hydrolysis and non-specific cleavage. | Doxorubicin | kallikrein related peptidase 3 | Homo sapiens |
| 4 | We believe that this strategy holds great promise in bypassing any systemic toxicity concerns that could arise from the premature activation of the prodrug whilst simultaneously being able to control the spatiotemporal context of Dox-PSA cleavage and metabolism. | Doxorubicin | kallikrein related peptidase 3 | Homo sapiens |