Title : Identification of AGT and CD44 in methotrexate-resistant colorectal cancer and reversal of methotrexate-resistance.

Pub. Date : 2022 Jan

PMID : 34952427






2 Functional Relationships(s)
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1 CCK-8 assay was used to show MTX-resistant CRC cell viability following CD44 inhibitor (THIQ) and AGT inhibitor (O6-BG) treatments. 1,2,3,4-tetrahydroisoquinoline CD44 molecule (Indian blood group) Homo sapiens
2 This research screened out CD44 and AGT in MTX-resistant CRC cells by bioinformatics and suggested that the combination of MTX with O6-BG or THIQ could enhance the sensitivity of MTX-resistant CRC cells to MTX. 1,2,3,4-tetrahydroisoquinoline CD44 molecule (Indian blood group) Homo sapiens