Pub. Date : 2021
PMID : 34951394
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of Methadone Maintenance on Expression of BDNF and CREB Genes in Brain VTA of Male Morphine Treated Rats. | Morphine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 2 | BACKGROUND: Morphine independent reduces the expression level of Brain-derived Neurotrophic Factor (BDNF) and Cyclic-AMP Response Element Binding protein (CREB). | Morphine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 3 | BACKGROUND: Morphine independent reduces the expression level of Brain-derived Neurotrophic Factor (BDNF) and Cyclic-AMP Response Element Binding protein (CREB). | Morphine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 4 | Therefore, this study was conducted to examine the effect of methadone maintenance on the expression of BDNF and CREB genes in brain VTA of male morphine treated rats. | Morphine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 5 | METHODS: I Morphine independent reduces the expression level of Brain-derived Neurotrophic Factor (BDNF) and Cyclic-AMP Response Element Binding protein (CREB). | Morphine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 6 | METHODS: I Morphine independent reduces the expression level of Brain-derived Neurotrophic Factor (BDNF) and Cyclic-AMP Response Element Binding protein (CREB). | Morphine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 7 | Therefore, this study was conducted to examine the effect of methadone maintenance on the expression of BDNF and CREB genes in brain VTA of male morphine treated rats Results: According to the findings of this study, similar to morphine treated group, methadone maintenance in morphine treated animals led to significant reduction in the expression of BDNF and CREB genes at VTA as well as BDNF serum level compared with control group. | Morphine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 8 | Therefore, this study was conducted to examine the effect of methadone maintenance on the expression of BDNF and CREB genes in brain VTA of male morphine treated rats Results: According to the findings of this study, similar to morphine treated group, methadone maintenance in morphine treated animals led to significant reduction in the expression of BDNF and CREB genes at VTA as well as BDNF serum level compared with control group. | Morphine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 9 | Therefore, this study was conducted to examine the effect of methadone maintenance on the expression of BDNF and CREB genes in brain VTA of male morphine treated rats Results: According to the findings of this study, similar to morphine treated group, methadone maintenance in morphine treated animals led to significant reduction in the expression of BDNF and CREB genes at VTA as well as BDNF serum level compared with control group. | Morphine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 10 | CONCLUSION: It was concluded that methadone, like morphine, causes significant reduction in the expression of BDNF and CREB genes in brain VTA area of rat as well as BDNF serum level compared with control group. | Morphine | cAMP responsive element binding protein 1 | Rattus norvegicus |