Title : Control of β-Site Amyloid Precursor Protein-Cleaving Enzyme-1 Expression by Protein Kinase C-λ/ι and Nuclear Factor κ-B.

Pub. Date : 2021

PMID : 34951366






1 Functional Relationships(s)
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1 METHODS: Reportedly, acute insulin treatment in normal mice, and hyperinsulinemia in high-fat-fed (HFF) obese/diabetic mice, increase BACE1 activity and levels of Abeta-peptides and phospho- -thr-231-tau in the brain; moreover, these effects are blocked by PKC-lambda/iota inhibitors. Threonine insulin Homo sapiens