Title : Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled Receptor D Induces Release of the Inflammatory Cytokine IL-6 and Is Dependent on NF-κB Signaling.

Pub. Date : 2021 Dec 9

PMID : 34948051






3 Functional Relationships(s)
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1 By stimulating human MRGPRD-expressing HeLa cells with the agonist beta-alanine, we observed a release of IL-6. beta-Alanine MAS related GPR family member D Homo sapiens
2 beta-alanine-induced signaling through MRGPRD was investigated further by probing downstream signaling effectors along the Galphaq/Phospholipase C (PLC) pathway, which results in an IkB kinases (IKK)-mediated canonical activation of nuclear factor kappa-B (NF-kappaB) and stimulation of IL-6 release. beta-Alanine MAS related GPR family member D Homo sapiens
3 Consequently, the dynamic range for IL-6 detection as an assay for beta-alanine-mediated activation of MRGPRD is substantially increased by culturing the cells in FBS free medium before treatment. beta-Alanine MAS related GPR family member D Homo sapiens