Title : Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.

Pub. Date : 2022 Jan 13

PMID : 34931827






1 Functional Relationships(s)
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1 Cancer cell proliferation in some organs often depends on conversion of pyruvate to oxaloacetate via pyruvate carboxylase (PC) for replenishing the tricarboxylic acid cycle to support biomass production. Oxaloacetic Acid pyruvate carboxylase Homo sapiens