Title : Synergistic responses in human platelets. Comparison between aggregation, secretion and cytosolic Ca2+ concentration.

Pub. Date : 1986 Dec 1

PMID : 3490977






3 Functional Relationships(s)
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1 Adrenaline, when added prior to non-saturating concentrations of U46619, thrombin, vasopressin or ADP, significantly enhances the increase in cytosolic [Ca2+] induced by these agonists in platelets suspended in media containing less than 0.1 microM or 1 mM Ca2+. Epinephrine coagulation factor II, thrombin Homo sapiens
2 Enhancement by adrenaline of Ca2+ influx induced by U46619, thrombin and ADP has been shown by using Mn2+ as probe. Epinephrine coagulation factor II, thrombin Homo sapiens
3 Adrenaline also enhances the extent of [3H]5HT secretion induced by U46619, thrombin and vasopressin but fails to increase that induced by ADP in this aspirin-treated preparation. Epinephrine coagulation factor II, thrombin Homo sapiens