Pub. Date : 2021
PMID : 34909677
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ATP citrate lyase inhibitor Bempedoic Acid alleviate long term HFD induced NASH through improvement in glycemic control, reduction of hepatic triglycerides & total cholesterol, modulation of inflammatory & fibrotic genes and improvement in NAS score. | 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid | ATP citrate lyase | Homo sapiens |
| 2 | Bempedoic acid (ETC-1002), a ATP citrate lyase (ACLY) inhibitor that lowers the LDL cholesterol was recently approved by US FDA for the treatment of heterozygous familial hypercholesterolemia (HeFH) and established atherosclerotic cardiovascular disease (ASCVD). | 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid | ATP citrate lyase | Homo sapiens |
| 3 | Bempedoic acid (ETC-1002), a ATP citrate lyase (ACLY) inhibitor that lowers the LDL cholesterol was recently approved by US FDA for the treatment of heterozygous familial hypercholesterolemia (HeFH) and established atherosclerotic cardiovascular disease (ASCVD). | 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid | ATP citrate lyase | Homo sapiens |
| 4 | Bempedoic acid (ETC-1002), a ATP citrate lyase (ACLY) inhibitor that lowers the LDL cholesterol was recently approved by US FDA for the treatment of heterozygous familial hypercholesterolemia (HeFH) and established atherosclerotic cardiovascular disease (ASCVD). | 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid | ATP citrate lyase | Homo sapiens |
| 5 | Bempedoic acid (ETC-1002), a ATP citrate lyase (ACLY) inhibitor that lowers the LDL cholesterol was recently approved by US FDA for the treatment of heterozygous familial hypercholesterolemia (HeFH) and established atherosclerotic cardiovascular disease (ASCVD). | 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid | ATP citrate lyase | Homo sapiens |
| 6 | ACLY is one of the genes modulated in NASH patients and hence we studied the effect of ACLY inhibitor Bempedoic acid in long term HFD induced NASH animal model to understand the pharmacological benefits and the associated mechanism of action of this newly approved drug in NASH. | 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid | ATP citrate lyase | Homo sapiens |