Title : Perillyl Alcohol Attenuates NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental In Vitro and In Vivo Models of Parkinson's Disease.

Pub. Date : 2022 Jan 5

PMID : 34904823






3 Functional Relationships(s)
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1 Hence, the present study aimed to investigate the role of lipopolysaccharide (LPS) and hydrogen peroxide (H2O2) in activating NLRP3 inflammasome-driven neurodegeneration and elucidated the neuroprotective role of perillyl alcohol (PA) in in vitro and in vivo models of Parkinson"s disease (PD). Hydrogen Peroxide NLR family, pyrin domain containing 3 Mus musculus
2 Hence, the present study aimed to investigate the role of lipopolysaccharide (LPS) and hydrogen peroxide (H2O2) in activating NLRP3 inflammasome-driven neurodegeneration and elucidated the neuroprotective role of perillyl alcohol (PA) in in vitro and in vivo models of Parkinson"s disease (PD). Hydrogen Peroxide NLR family, pyrin domain containing 3 Mus musculus
3 Initial priming of microglial cells with LPS following treatment with H2O2 induced NF-kappaB translocation to the nucleus with a robust generation of free radicals that act as signal 2 in augmenting NLRP3 inflammasome assembly and its downstream targets. Hydrogen Peroxide NLR family, pyrin domain containing 3 Mus musculus