Pub. Date : 2022 Jan
PMID : 34896572
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Results showed that Tween 80 exhibited non-competitive inhibition on the doxorubicin efflux of P-gp and MRP1, with the inhibitory affinity 0.00195% (14.89 muM) and 0.00245% (18.7 muM), respectively. | Polysorbates | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Results showed that Tween 80 exhibited non-competitive inhibition on the doxorubicin efflux of P-gp and MRP1, with the inhibitory affinity 0.00195% (14.89 muM) and 0.00245% (18.7 muM), respectively. | Polysorbates | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Tween 80 inhibited the basal ATPase activity of P-gp and MRP1 in a dose-dependent manner (0.0002% to 0.02%) and demonstrated significant reversing effects on the doxorubicin, paclitaxel, and vincristine resistance at the concentration of 0.001% (7.63 muM). | Polysorbates | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Tween 80 inhibited the basal ATPase activity of P-gp and MRP1 in a dose-dependent manner (0.0002% to 0.02%) and demonstrated significant reversing effects on the doxorubicin, paclitaxel, and vincristine resistance at the concentration of 0.001% (7.63 muM). | Polysorbates | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | This was the first thorough study revealing the interactions between Tween 80 and P-gp or MRP1 at a molecular level and these findings suggested that Tween 80 was a potential candidate for future combinatorial regimens applied in the "drug resistance" issue. | Polysorbates | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | This was the first thorough study revealing the interactions between Tween 80 and P-gp or MRP1 at a molecular level and these findings suggested that Tween 80 was a potential candidate for future combinatorial regimens applied in the "drug resistance" issue. | Polysorbates | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | This was the first thorough study revealing the interactions between Tween 80 and P-gp or MRP1 at a molecular level and these findings suggested that Tween 80 was a potential candidate for future combinatorial regimens applied in the "drug resistance" issue. | Polysorbates | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 8 | This was the first thorough study revealing the interactions between Tween 80 and P-gp or MRP1 at a molecular level and these findings suggested that Tween 80 was a potential candidate for future combinatorial regimens applied in the "drug resistance" issue. | Polysorbates | ATP binding cassette subfamily B member 1 | Homo sapiens |