Title : Repositioning application of polyoxyethylene (20) sorbitan monooleate on ocular drug resistance and cancer multi-drug resistance by inhibiting the ATPase activity of human multidrug resistance protein 1 and P-glycoprotein.

Pub. Date : 2022 Jan

PMID : 34896572






2 Functional Relationships(s)
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1 Results showed that Tween 80 exhibited non-competitive inhibition on the doxorubicin efflux of P-gp and MRP1, with the inhibitory affinity 0.00195% (14.89 muM) and 0.00245% (18.7 muM), respectively. Doxorubicin ATP binding cassette subfamily B member 1 Homo sapiens
2 Results showed that Tween 80 exhibited non-competitive inhibition on the doxorubicin efflux of P-gp and MRP1, with the inhibitory affinity 0.00195% (14.89 muM) and 0.00245% (18.7 muM), respectively. Doxorubicin ATP binding cassette subfamily B member 1 Homo sapiens