Title : Design of a protein-targeted DNA aptamer using atomistic simulation.

Pub. Date : 2021 Dec 11

PMID : 34895068






1 Functional Relationships(s)
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1 However, thrombin"s aptamer binding site is lined by two tryptophan residues and the conjugation of bulky osmium groups to these residues weakens aptamer binding by an estimated 4 to 12 kcal/mol, undermining detection sensitivity. Tryptophan coagulation factor II, thrombin Homo sapiens