Title : Nickel-Catalyzed Stereo- and Enantioselective Cross-Coupling of gem-Difluoroalkenes with Carbon Electrophiles by C-F Bond Activation.

Pub. Date : 2022 Feb 1

PMID : 34889493






1 Functional Relationships(s)
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1 Treatment of gem-difluoroalkenes with racemic benzyl electrophiles in the presence of a chiral nickel complex using B 2 pin 2 as a stoichiometric reductant allows the construction of a C(sp 2 )-C(sp 3 ) bond under mild conditions, affording a broad range of monofluoroalkenes bearing stereogenic allylic centers. Nickel Sp2 transcription factor Homo sapiens