Title : Methylene blue decreases the functional activity of alpha-1-protease inhibitor in bronchoalveolar lavage.

Pub. Date : 1986 Aug

PMID : 3488702






6 Functional Relationships(s)
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1 Methylene blue, used as an external marker for bronchoalveolar lavage (BAL) in a concentration of 1 microgram/ml, reduced the functional activity of BAL alpha 1-protease inhibitor (alpha 1-PI) in 2 healing nonsmokers who each had 2 BAL done, one with and the other without methylene blue. Methylene Blue serpin family A member 1 Homo sapiens
2 Methylene blue, used as an external marker for bronchoalveolar lavage (BAL) in a concentration of 1 microgram/ml, reduced the functional activity of BAL alpha 1-protease inhibitor (alpha 1-PI) in 2 healing nonsmokers who each had 2 BAL done, one with and the other without methylene blue. Methylene Blue serpin family A member 1 Homo sapiens
3 Methylene blue, used as an external marker for bronchoalveolar lavage (BAL) in a concentration of 1 microgram/ml, reduced the functional activity of BAL alpha 1-protease inhibitor (alpha 1-PI) in 2 healing nonsmokers who each had 2 BAL done, one with and the other without methylene blue. Methylene Blue serpin family A member 1 Homo sapiens
4 Inactivation of alpha 1-PI by methylene blue was confirmed by in vitro experiments on diluted serum and concentrated BAL incubated with methylene blue. Methylene Blue serpin family A member 1 Homo sapiens
5 Inactivation of alpha 1-PI by methylene blue was confirmed by in vitro experiments on diluted serum and concentrated BAL incubated with methylene blue. Methylene Blue serpin family A member 1 Homo sapiens
6 Inactivation of alpha 1-PI is likely due to its oxidation by methylene blue, as suggested by the in vitro protective effect of dithiothreitol, a reducing agent. Methylene Blue serpin family A member 1 Homo sapiens