Title : Fludarabine nucleoside induces major changes in the p53 interactome in human B-lymphoid cancer cell lines.

Pub. Date : 2022

PMID : 34886743






3 Functional Relationships(s)
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1 Results from our laboratory indicate that 2-FaraAMP (fludarabine) has multiple mechanisms of cytotoxicity that include accumulation of isoforms and phosphorylated derivatives of p53, and induction of the unfolded protein response (UPR). fludarabine tumor protein p53 Homo sapiens
2 Using protein pull-downs with Dynabeads coated with p53 antibody, we have found that 2-FaraA (fludarabine nucleoside) induces major changes in the p53 interactome in human Raji lymphoma and IM9 multiple myeloma cells. fludarabine tumor protein p53 Homo sapiens
3 Using protein pull-downs with Dynabeads coated with p53 antibody, we have found that 2-FaraA (fludarabine nucleoside) induces major changes in the p53 interactome in human Raji lymphoma and IM9 multiple myeloma cells. fludarabine tumor protein p53 Homo sapiens