Title : Dityrosine Crosslinking of Collagen and Amyloid-β Peptides Is Formed by Vitamin B12 Deficiency-Generated Oxidative Stress in Caenorhabditis elegans.

Pub. Date : 2021 Nov 30

PMID : 34884761






3 Functional Relationships(s)
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1 Moreover, using GMC101 mutant worms that express the full-length human amyloid beta, we found that vitamin B12 deficiency did not affect the gene and protein expressions of amyloid beta but increased the formation of dityrosine crosslinking in the amyloid beta protein. dityrosine amyloid beta precursor protein Homo sapiens
2 Moreover, using GMC101 mutant worms that express the full-length human amyloid beta, we found that vitamin B12 deficiency did not affect the gene and protein expressions of amyloid beta but increased the formation of dityrosine crosslinking in the amyloid beta protein. dityrosine amyloid beta precursor protein Homo sapiens
3 In GMC101 mutant worms, vitamin B12 deficiency-induced oxidative stress triggers dityrosine-crosslinked amyloid beta formation, which might promote its stabilization and toxic oligomerization. dityrosine amyloid beta precursor protein Homo sapiens