Title : In Vitro and In Vivo Assessment of Atemoya Fruit (Annona atemoya) for Food-Drug Interactions.

Pub. Date : 2022 Mar

PMID : 34881402






2 Functional Relationships(s)
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1 Meanwhile, preadministration of fluvoxamine significantly extended the time needed for the elimination of phenacetin, possibly due to the inhibition of CYP1A2. Fluvoxamine cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus
2 This suggests that the intake of an excess amount of atemoya juice is necessary to cause a change in the pharmacokinetics of phenacetin when the IC50 values for CYP1A2 inhibition by atemoya and fluvoxamine are taken into account. Fluvoxamine cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus