Pub. Date : 2022 Feb
PMID : 34864562
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Protegrin-1 inhibits porcine ovarian granulosa cell apoptosis from H2O2-induced oxidative stress via the PERK/eIF2alpha/CHOP signaling pathway in vitro. | Hydrogen Peroxide | eukaryotic translation initiation factor 2A | Homo sapiens |
| 2 | Using Western blot analysis, it was found that PG-1 decreased the phosphorylation of RNA-like endoplasmic reticulum kinase (PERK) and the alpha-subunit of eukaryotic initiation factor 2 (eIF2alpha) as well as the protein expression level of CCAAT enhancer-binding protein homologous protein (CHOP), all of which were increased by H2O2. | Hydrogen Peroxide | eukaryotic translation initiation factor 2A | Homo sapiens |
| 3 | Moreover, inhibitors against PERK and phospho-eIF2alpha both suppressed the H2O2-induced granulosa cells apoptosis and enhanced the anti-apoptosis effect of PG-1. | Hydrogen Peroxide | eukaryotic translation initiation factor 2A | Homo sapiens |