Title : Extracellular cathepsin Z signals through the α5 integrin and augments NLRP3 inflammasome activation.

Pub. Date : 2022 Jan

PMID : 34864055






1 Functional Relationships(s)
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1 We report that the lysosomal cysteine protease cathepsin Z potentiates the development of inflammation associated with respiratory silicosis by augmenting NLRP3 inflammasome-derived IL-1beta expression in response to silica. Silicon Dioxide NLR family pyrin domain containing 3 Homo sapiens