Title : Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).

Pub. Date : 2021 Dec 3

PMID : 34862374






1 Functional Relationships(s)
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1 PRIMA-1 and eprenetapopt (APR-246/PRIMA-1MET) are small molecules that are converted into the biologically active compound, methylene quinuclidinone (MQ), shown to reactivate mutant p53 by binding covalently to cysteine residues. Cysteine tumor protein p53 Homo sapiens